Synthesis of sterically congested 1,5-disubstituted-1,2,3-Triazoles using chloromagnesium acetylides and hindered 1-naphthyl azides

Publication Name

Tetrahedron

Abstract

Sterically congested 1-(2-methoxy-1-naphthyl)-5-substituted-1,2,3-triazoles can be prepared from sterically hindered 2-methoxy-1-azidonaphthalene and chloromagnesium acetylides, including 2-substituted phenylacetylides. Catalytic methods using Cp∗RuCl(PPh ) or Cp Ni/Xanphos were not successful. 3 2 2

Open Access Status

This publication is not available as open access

Volume

81

Article Number

131916

Funding Number

APP1124032

Funding Sponsor

National Health and Medical Research Council

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.tet.2020.131916