Title

Unique polyacetylenic ester-neolignan derivatives from Mitrephora tomentosa and their antimalarial activities

Publication Name

Phytochemistry

Abstract

The phytochemical investigation of the methanol extracts of the leaves and twigs of Mitrephora tomentosa Hook. f. & Thomson resulted in the isolation and identification of undescribed polyacetylenic ester-neolignan derivatives, along with six known compounds. These six undescribed natural products were named as mitrephentosins A-F. The structures of these compounds were determined by spectroscopic techniques including UV, IR, NMR, and mass spectrometric analyses. The absolute configurations of mitrephentosins A-F were determined based on specific rotations values and ECD spectral data by comparisons made with the known parent neoligan compound mitredrusin. Mitrephentosins C, E, and F showed moderate antimalarial activities (IC values of 13.3–24.6 μM) against the Plasmodium falciparum strains TM4/8.2 and K1CB1 and were not toxic to Vero cells, while the other isolated compounds were not active against these P. falciparum strains. 50

Open Access Status

This publication is not available as open access

Volume

183

Article Number

112615

Funding Number

P1850116

Funding Sponsor

Chiang Mai University

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.phytochem.2020.112615