Title

Towards high spatial resolution tissue-equivalent dosimetry for microbeam radiation therapy using organic semiconductors

Publication Name

Journal of Synchrotron Radiation

Abstract

Spatially fractionated ultra-high-dose-rate beams used during microbeam radiation therapy (MRT) have been shown to increase the differential response between normal and tumour tissue. Quality assurance of MRT requires a dosimeter that possesses tissue equivalence, high radiation tolerance and spatial resolution. This is currently an unsolved challenge. This work explored the use of a 500nm thick organic semiconductor for MRT dosimetry on the Imaging and Medical Beamline at the Australian Synchrotron. Three beam filters were used to irradiate the device with peak energies of 48, 76 and 88keV with respective dose rates of 3668, 500 and 209Gys-1. The response of the device stabilized to 30% efficiency after an irradiation dose of 30kGy, with a 0.5% variation at doses of 35kGy and higher. The calibration factor after pre-irradiation was determined to be 1.02±0.005μGy per count across all three X-ray energy spectra, demonstrating the unique advantage of using tissue-equivalent materials for dosimetry. The percentage depth dose curve was within ±5% of the PTW microDiamond detector. The broad beam was fractionated into 50 microbeams (50μm FHWM and 400μm centre-to-centre distance). For each beam filter, the FWHMs of all 50 microbeams were measured to be 51±1.4, 53±1.4 and 69±1.9μm, for the highest to lowest dose rate, respectively. The variation in response suggested the photodetector possessed dose-rate dependence. However, its ability to reconstruct the microbeam profile was affected by the presence of additional dose peaks adjacent to the one generated by the X-ray microbeam. Geant4 simulations proved that the additional peaks were due to optical photons generated in the barrier film coupled to the sensitive volume. The simulations also confirmed that the amplitude of the additional peak in comparison with the microbeam decreased for spectra with lower peak energies, as observed in the experimental data. The material packaging can be optimized during fabrication by solution processing onto a flexible substrate with a non-fluorescent barrier film. With these improvements, organic photodetectors show promising prospects as a cost-effective high spatial resolution tissue-equivalent flexible dosimeter for synchrotron radiation fields.

Open Access Status

This publication is not available as open access

Volume

28

First Page

1444

Last Page

1454

Funding Number

AS193/IMBL/15240

Funding Sponsor

Australian Nuclear Science and Technology Organisation

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Link to publisher version (DOI)

http://dx.doi.org/10.1107/S1600577521006044