Title
The Detosylation of Chiral 1,2-Bis(tosylamides)
Publication Name
Journal of Organic Chemistry
Abstract
The deprotection of chiral 1,2-bis(tosylamides) to their corresponding 1,2-diamines is mostly unsuccessful under standard conditions. In a new methodology, the use of Mg/MeOH with sufficient steric additions allows the facile synthesis of 1,2-diamines in 78-98% yields. These results are rationalized using density functional theory and the examination of inner and outer-sphere reduction mechanisms.
Open Access Status
This publication is not available as open access
Volume
86
Issue
13
First Page
9163
Last Page
9180