Title

Traveling Wave Solutions in a Model for Tumor Invasion with the Acid-Mediation Hypothesis

Publication Name

Journal of Dynamics and Differential Equations

Abstract

In this manuscript, we prove the existence of slow and fast traveling wave solutions in the original Gatenby–Gawlinski model. We prove the existence of a slow traveling wave solution with an interstitial gap. This interstitial gap has previously been observed experimentally, and here we derive its origin from a mathematical perspective. We give a geometric interpretation of the formal asymptotic analysis of the interstitial gap and show that it is determined by the distance between a layer transition of the tumor and a dynamical transcritical bifurcation of two components of the critical manifold. This distance depends, in a nonlinear fashion, on the destructive influence of the acid and the rate at which the acid is being pumped.

Open Access Status

This publication may be available as open access

Funding Number

20-11027X

Funding Sponsor

Australian Research Council

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/s10884-021-10003-7