This article discusses the potential application of Chronic Care Model (CCM) for self-management of type 2 diabetes focusing on the middle-aged population of rural area of Pakistan. The article further highlights the variations of chronic care model and the evidence for its efficacy and elaborating the elements of the model that are used in primary health care. The features of Chronic Care Model (CCM) have been highlighted including the socio-ecological approach to diabetes self-management and community-based partnership for improving chronic disease management. The two components of the chronic care model such as patient self-management support (SMS) and delivery system design (DSD) have been proposed for type 2 diabetes patients in the middle-aged population of rural area of Pakistan to see the effectiveness of their intervention in improving the patient quality of life, risk behaviour and knowledge and adherence to treatment. The chronic care model offers an ideal framework to support diabetes self-management education and support because it provides a sound basis on which to promote self-management.