The systematic literature review was carried out to identify and analyse qualitative and quantitative articles published in the last 20 years relevant to the self-management of type 2 diabetes. The aim of this review was to identify and synthesize the contemporary qualitative and quantitative research on the self-management of type 2 diabetes focusing on the factors that play an important role in self-management of diabetes in Pakistan. This systematic review synthesized the knowledge and identified the gap in the literature regarding type 2 diabetes self-management among the middle-aged population of Pakistan. The review has revealed that there is lack of studies in literature on self-management of type 2 diabetes in Pakistan. This review will be useful for health care professionals suggesting that coping with diagnosis and living with diabetes is affected by a complex constellation of factors, including life circumstances, social support, gender roles and economy.