Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones

Authors

Ronald Brown, University of WollongongFollow
Farzad Zamani, University of WollongongFollow
Michael G. Gardiner, Australian National University
Haibo Yu, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow
Christopher J. T Hyland, University of WollongongFollow

RIS ID

139630

Publication Details

Brown, R. W., Zamani, F., Gardiner, M. G., Yu, H., Pyne, S. G. & Hyland, C. J.T. (2019). Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones. Chemical Science, 10 (39), 9051-9056.

Abstract

The divergent reactivity of 5-allenyloxazolidinones has been explored. This novel building block undergoes Pd(0)-catalyzed cross-coupling with boronic acids to form a wide range of chiral 1,3-dienes and pharmaceutically useful vinyloxazolidinones, the chemoselectivity being tightly controlled by a simple switch in additive.

Grant Number

ARC/DP180101332