Title

Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume

RIS ID

137376

Publication Details

O'Hara, K., Schneider, J. J., Jones, A. L., Wright, I. M. R., Martin, J. H. & Galettis, P. (2019). Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume. Journal of Liquid Chromatography and Related Technologies, 42 (15-16), 521-527.

Abstract

Remifentanil is a short acting opioid currently used in anesthesia and as an analgesic. This paper describes a simple, fast HPLC-MS/MS methodology that allows detection of remifentanil in low volume plasma samples. Acetonitrile protein precipitation is used for sample extraction and clean up. The assay has a lower limit of detection of 0.25 ng/mL and a 3 min run time.

Please refer to publisher version or contact your library.

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1080/10826076.2019.1631178