α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis

Authors

Pornphimol Meesakul, University of Wollongong, Mae Fah Luang University
Christopher Richardson, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow
Surat Laphookhieo, Mae Fah Luang UniversityFollow

RIS ID

134226

Publication Details

Meesakul, P., Richardson, C., Pyne, S. G. & Laphookhieo, S. (2019). α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis. Journal of Natural Products, 82 (4), 741-747.

Abstract

Four new flavonoids (1-4), a new benzyl benzoate derivative (5), five new oxepinones (6-10), and 14 known compounds (11-24) were isolated from the leaf and twig extracts of Desmos cochinchinensis. Their structures were established by spectroscopic methods. The structure of 1 was also confirmed by X-ray diffraction data. The absolute configurations of 3, 4, and 6-10 were determined from comparisons of their ECD spectra with those of relevant reported compounds. Compounds 1, 2, 6, 8, 10, 12-15, and 17 showed α-glucosidase inhibitory activities with IC 50 values ranging from 0.2 to 4.9 μM.