Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis
Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield (-)-1 and (+)-1 and (-)-2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of (-)-2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-κB inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells).
Publication Details Citation
Jaidee, W., Andersen, R. J., Chavez, M., Wang, Y., Patrick, B. O., Pyne, S. G., Muanprasat, C., Borwornpinyo, S., & Laphookhieo, S. (2019). Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis. Faculty of Science, Medicine and Health - Papers: Part B. https://doi.org/10.1021/acs.jnatprod.8b00696. Retrieved from https://ro.uow.edu.au/smhpapers1/558