Title

Dual Gold-Catalyzed Cycloaromatization of Unconjugated (E)-Enediynes

RIS ID

132562

Publication Details

Zamani, F., Babaahmadi, R., Yates, B. F., Gardiner, M. G., Ariafard, A., Pyne, S. G. & Hyland, C. J. T. (2019). Dual Gold-Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes. Angewandte Chemie International Edition, 58 (7), 2114-2119.

Abstract

A synthesis of novel unconjugated (E)‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode involving a key gold‐vinylidene and allenyl‐gold containing intermediate.

Grant Number

ARC/DP180101332

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