Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus

Authors

Thanika Promchai, Chiang Mai University
Pawinee Janhom, Chiang Mai University
Wisanu Maneerat, Mae Fah Luang University
Roonglawan Rattanajak, National Science and Technology Development Agency
Sumalee Kamchonwongpaisan, National Science and Technology Development Agency
Stephen G. Pyne, University of WollongongFollow
Thunwadee Limtharakul, Chiang Mai University

RIS ID

132445

Publication Details

Promchai, T., Janhom, P., Maneerat, W., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Limtharakul, T. (2018). Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus. Natural Product Research, Online First 1-5.

Abstract

A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.