RIS ID

132407

Publication Details

Meesakul, P., Pyne, S. G. & Laphookhieo, S. (2018). Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii. Natural Product Research, Online First 1-5.

Abstract

The phytochemical investigation of the leaf extracts of Uvaria hamiltonii (Annonaceae) led to the isolation and identification of ten compounds including a new seco-cyclohexene (1) together with nine known compounds (2-10). Their structures were elucidated by intensive analysis by spectroscopic methods and comparisons of their spectroscopic data with those of compounds reported in the literature. Compounds 2, 8, and 9 showed potent α-glucosidase inhibitory activity with the IC50 values ranging from 2.6-7.1 µM.

Available for download on Monday, December 23, 2019

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Link to publisher version (DOI)

http://dx.doi.org/10.1080/14786419.2018.1538996