RIS ID

130170

Publication Details

Khalili, G., Willis, A. C. & Keller, P. A. (2018). Design and synthesis of new functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives. Monatshefte für Chemie, Online First 1-9.

Abstract

A library of N,N-substituted isoindigo derivatives were prepared by reaction of isoindigo with a variety of alkylating agents in the presence of MeONa under mild conditions in yields of 65-80%. A new, more efficient synthesis of (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) is described by reaction of oxindole with glyoxal at reflux in methanol-a small library of N,N′-substituted derivatives were also prepared in 60-70% yield.

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/s00706-018-2272-1