The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.
Publication Details Citation
Raksat, A., Maneerat, W., Andersen, R. J., Pyne, S. G., & Laphookhieo, S. (2018). Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa. Faculty of Science, Medicine and Health - Papers: Part B. https://doi.org/10.1021/acs.jnatprod.8b00321. Retrieved from https://ro.uow.edu.au/smhpapers1/186
Available for download on Wednesday, August 14, 2019