Title

Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature

RIS ID

143993

Publication Details

Przybyla, M., Van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A., Muller, J., Gajwani, M., Prikas, E., Mueller, T., Stevens, C., Power, J., Housley, G., Karl, T., Kassiou, M., Ke, Y., Ittner, A. & Ittner, L. (2020). Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain, 143 (6), 1889-1904.

Abstract

© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com. Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer's disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that recapitulate aspects of human neurodegenerative diseases, including tau hyperphosphorylation and neurofibrillary tangle formation. Here, we characterized the effects of transgenic P301S mutant human tau expression on neuronal network function in the murine hippocampus. Onset of progressive spatial learning deficits in P301S tau transgenic TAU58/2 mice were paralleled by long-term potentiation deficits and neuronal network aberrations during electrophysiological and EEG recordings. Gene-expression profiling just prior to onset of apparent deficits in TAU58/2 mice revealed a signature of immediate early genes that is consistent with neuronal network hypersynchronicity. We found that the increased immediate early gene activity was confined to neurons harbouring tau pathology, providing a cellular link between aberrant tau and network dysfunction. Taken together, our data suggest that tau pathology drives neuronal network dysfunction through hyperexcitation of individual, pathology-harbouring neurons, thereby contributing to memory deficits.

Please refer to publisher version or contact your library.

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1093/brain/awaa133