Palladium-Catalyzed Decarboxylative Formal (4 + 2) Cycloaddition of Vinyl Benzoxazinanones with 3-Nitroindoles
© 2020. Thieme. All rights reserved. A diastereoselective palladium-catalyzed dearomative formal (4 + 2) cycloaddition between vinyl benzoxazinanones and 3-nitroindoles has been developed. This reaction provides a concise route to tetrahydro-5 H-indolo[2,3-b ]quinolines in excellent yield (up to 94%) and diastereoselectivity (up to >98:2), with versatile functional handles including vinyl, nitro, and free NH groups.