68Ga-Prostate-Specific Membrane Antigen Uptake in Cerebral Tuberculosis

Veronica Wong
Lily Shen
Elias H. Nasser, University of Wollongong
David N. Adams, University of Wollongong
Robert Mansberg

Wong, V., Shen, L., Nasser, E., Adams, D. N. & Mansberg, R. (2020). 68Ga-Prostate-Specific Membrane Antigen Uptake in Cerebral Tuberculosis. Clinical nuclear medicine, 45 (3), 238-240.

Abstract

A 71-year-old man with a history of high-risk prostate adenocarcinoma (Gleason score 4 + 5 = 9) treated with brachytherapy in 2016 was referred for a Ga-prostate-specific membrane antigen (PSMA)-HBED-CC PET/CT scan for suspected cancer recurrence on a background of slowly rising serum prostate-specific antigen (0.95 ng/mL; reference, <0.2 ng/mL). This revealed PSMA-avid dura-based hyperdense lesions in the brain, suggestive of cerebral metastases. Biopsy demonstrated the presence of acid-fast bacilli, and with further clinical and microbiological testing, a diagnosis of PSMA-avid cerebral tuberculous mycobacterium infection was made.