RIS ID
141424
Abstract
The quality of biomolecular simulations critically depends on the accuracy of the force field used to calculate the potential energy of the molecular configurations. Currently, most simulations employ non-polarisable force fields, which describe electrostatic interactions as the sum of Coulombic interactions between fixed atomic charges. Polarisation of these charge distributions is incorporated only in a mean-field manner. In the past decade, extensive efforts have been devoted to developing simple, efficient, and yet generally applicable polarisable force fields for biomolecular simulations. In this review, we summarise the latest developments in accounting for key biomolecular interactions with polarisable force fields and applications to address challenging biological questions. In the end, we provide an outlook for future development in polarisable force fields.
Grant Number
ARC/DP170101773
Grant Number
NHMRC/1145760
Publication Details
Inakollu, V. S., Geerke, D. P., Rowley, C. N. & Yu, H. (2020). Polarisable force fields: what do they add in biomolecular simulations?. Current Opinion in Structural Biology, 61 182-190.