Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum

Authors

Virayu Suthiphasilp, Mae Fah Luang University
Wisanu Maneerat, Mae Fah Luang University
Raymond J. Andersen, University of British Columbia
Piyaporn Phukhatmuen, Mae Fah Luang University
Stephen G. Pyne, University of WollongongFollow
Surat Laphookhieo, Mae Fah Luang UniversityFollow

RIS ID

140072

Publication Details

Suthiphasilp, V., Maneerat, W., Andersen, R. J., Phukhatmuen, P., Pyne, S. G. & Laphookhieo, S. (2019). Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum. Journal of Natural Products, 82 (11), 3176-3180.

Abstract

Five new aristolactam alkaloids (1-5), dasymaschalolactams A-E, and the first isolation of dasymaschalolactone (17) as a natural product, together with 19 known compounds (6-16 and 18-25) were isolated from the twig extract of Dasymaschalon dasymaschalum. Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. Compounds 20 and 21 showed α-glucosidase inhibitory activities with IC50 values of 4.5 and 24.7 μM, respectively.