Title

Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?

RIS ID

123755

Publication Details

Tsatsaronis, J. A., Franch-Arroyo, S., Resch, U. & Charpentier, E. (2018). Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?. Trends in Microbiology, 26 (5), 401-410.

Abstract

Both extracellular RNAs and extracellular vesicles (EVs) have recently garnered attention as novel mediators of intercellular communication in eukaryotes and prokaryotes alike. EVs not only permit export of RNA, but also facilitate delivery and trans-kingdom exchange of these and other biomolecules, for instance between microbes and their hosts. In this Opinion article, we propose that EV-mediated export of RNA represents a universal mechanism for interkingdom and intrakingdom communication that is conserved among bacterial, archaeal, and eukaryotic microbes. We speculate how microbes might use EV RNA to influence target cell gene expression or manipulate host immune responses.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.tim.2018.02.009