How DNA-repair proteins find their targets



Publication Details

Quessada-Vial, A. & van Oijen, A. M. (2012). How DNA-repair proteins find their targets. Proceedings of the National Academy of Sciences of USA, 109 (45), 18243-18244.


Genomic DNA is subject to damage at such high frequencies that only with efficient DNA-repair pathways genomic stability is maintained. Research efforts of many groups over several decades have revealed the salient properties of the various DNA-repair mechanisms, but it has largely remained unclear how damage sites are localized in genomic DNA. In PNAS, Gorman et al. (1) unveil insights into the DNA-repair process called mismatch repair (MMR), which is responsible for the repair of incorrectly paired DNA bases. They use a combination of single-molecule fluorescence imaging and nanofabrication to study how different search mechanisms are used in eukaryotic MMR to find mismatches.

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