Publication Details

Sluyter, R. & Watson, D. (2014). T Cells continue to play on the ATP circuit. Journal of Immune Research, 1 (1), 1-2.


The generation of immune responses involves the coordinated communication between cells through direct cell-to-cell contact and the release of various soluble factors binding to their respective receptors. Of the many soluble factors and receptors known, there is growing evidence that the release of extracellular adenosine triphosphate (ATP) and its subsequent activation of cell-surface ligand-gated cation channels belonging to the family of P2X receptors (P2X1-7) play important roles in communication between immune cells [1]. Much of what is understood about the roles of extracellular ATP and the activation of P2X receptors during an immune response has been inferred from in vitro studies requiring the addition of exogenous ATP or from studies using rodent models of inflammation and immunity [2]. Nevertheless our understanding of the extracellular ATP-P2X receptor axes operating between immune cells, including CD4+ T cells, during immune responses is limited.