Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide

Authors

Nalivela Kumara Swamy, University of Wollongong
Stephen G. Pyne, University of WollongongFollow

RIS ID

50499

Publication Details

Swamy, N. Kumara. & Pyne, S. G. (2012). Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide. Heterocycles, 84 (1), 473-492.

Abstract

As part of a model study towards the total synthesis of Stemona alkaloid 1-hydroxyprotostemonine 1, we have achieved the synthesis an A-B-C ring precursor, ent-1-hydroxystemoamide. Key steps involve an ene-yne RCM reaction and a diastereoselective dihydroxylation-lactonization reaction.