Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin.
RIS ID
26764
Abstract
Chronic proteinuric renal injury is a major cause of ESRD. Adriamycin nephropathy is a murine model of chronic proteinuric renal disease whereby chemical injury is followed by immune and structural changes that mimic human disease. Foxp3 is a gene that induces a regulatory T cell (Treg) phenotype. It was hypothesized that Foxp3-transduced Treg could protect against renal injury in Adriamycin nephropathy. CD4+ T cells were transduced with either a Foxp3-containing retrovirus or a control retrovirus. Foxp3-transduced T cells had a regulatory phenotype by functional and phenotypic assays. Adoptive transfer of Foxp3-transduced T cells protected against renal injury. Urinary protein excretion and serum creatinine were reduced (P<0.05), and there was significantly less glomerulosclerosis, tubular damage, and interstitial infiltrates (P<0.01). It is concluded that Foxp3-transduced Treg cells may have a therapeutic role in protecting against immune injury and disease progression in chronic proteinuric renal disease.
Publication Details
Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Hori, S., Alexander, I., Harris, D. & Alexander, S. I. (2006). Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. Journal of the American Society of Nephrology, 17 (3), 697-706.