Antibacterial anthranilic acid derivatives from Geijera parviflora



Publication Details

Shou, Q., Banbury, L. K., Maccarone, A. T., Renshaw, D. E., Mon, H., Griesser, S., Griesser, H. J., Blanksby, S. J., Smith, J. E. & Wohlmuth, H. (2014). Antibacterial anthranilic acid derivatives from Geijera parviflora. Fitoterapia, 93 62-66.


Five anthranilic acid derivatives, a mixture I of three new compounds 11′-hexadecenoylanthranilic acid (1), 9′-hexadecenoylanthranilic acid (2), and 7′-hexadecenoylanthranilic acid (3), as well as a new compound 9,12,15-octadecatrienoylanthranilic acid (4) together with a new natural product, hexadecanoylanthranilic acid (5), were isolated from Geijera parviflora Lindl. (Rutaceae). Their structures were elucidated by extensive spectroscopic measurements, and the positions of the double bonds in compounds 1–3 of the mixture I were determined by tandem mass spectrometry employing ozone-induced dissociation. The mixture I and compound 5 showed good antibacterial activity against several Gram-positive strains.

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