What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity?

Authors

Chao Deng, University of WollongongFollow
J-Z Chen, University of WollongongFollow
Changhua Hu, University of Wollongong
Xu-Feng Huang, University of WollongongFollow

RIS ID

33045

Publication Details

Deng, C., Chen, J., Hu, C. & Huang, X. (2010). What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity?. Journal of Clinical Psychopharmacology, 30 (4), 480-481.

Abstract

We read with great interest Henderson and colleagues’ paper in your journal (2009; 29:165–169), which reported that aripiprazole reduced olanzapine-induced overweight/obesity and hyperlipidemia in a 10-week placebo-controlled double-blind crossover study. This and their previous studies, provide a new way for controlling olanzapine- and clozapine-induced weight gain/obesity using another atypical antipsychotic, even without reducing the original olanzapine and clozapine doses, which is important particularly for treatment of refractory schizophrenia patients. ....