Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment

Authors

Georgia Frangioudakis, Garvan Institute of Medical Research
Barbara Diakanastasis, Garvan Institute of Medical Research
Bing-Qing M. Liao, Garvan Institute of Medical Research
Jennifer T. Saville, University of WollongongFollow
Nolan J. Hoffman, Garvan Institute of Medical Research
Todd W. Mitchell, University of WollongongFollow
Carsten Schmitz-Peiffer, Garvan Institute of Medical Research

RIS ID

81858

Publication Details

Frangioudakis, G., Diakanastasis, B., Liao, B. M., Saville, J. T., Hoffman, N. J., Mitchell, T. W. and Schmitz-Peiffer, C. (2013). Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment. Diabetologia, 56 (12), 2697-2701.

Abstract

AIMS/HYPOTHESIS: An accumulation of ceramides has been implicated in the generation of insulin resistance in skeletal muscle upon an oversupply of fatty acid. Different ceramide species are generated through the actions of ceramide synthases (CerSs), which incorporate specific acyl side chains. We tested whether particular CerS isoforms promoted insulin resistance through the generation of more inhibitory ceramide species, thus representing potential targets for intervention.