Surface analyses and immune reactivities of major cell wall-associated proteins of Group A Streptococcus

Authors

J. N. Cole, University of WollongongFollow
R. D. Ramirez, University of Wollongong
B. J. Currie, Charles Darwin University
S. J. Cordwell, Macquarie University
S. P. Djordjevic, NSW Agriculture
Mark J. Walker, University of WollongongFollow

RIS ID

13141

Publication Details

This paper was originally published as Cole, JN, Ramirez, RD, Currie, BJ, Cordwel, SJ, Djordjevic, SP and Walker, MJ, Surface analyses and immune reactivities of major cell wall-associated proteins of Group A Streptococcus, Infection and Immunity, 73 (5), 2005, 3137-3146.

Abstract

A proteomic analysis was undertaken to identify cell-wall associated proteins of Streptococcus pyogenes. Seventy-four distinct cell-wall associated proteins were identified, 66 of which were novel. Thirty-three proteins were immunoreactive with pooled S. pyogenes-reactive human antisera. Biotinylation of the GAS cell-surface identified 23 cellwall associated proteins that are surface exposed.