Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor

Authors

Thunwadee Ritthiwigrom, University of WollongongFollow
Anthony C. Willis, Australian National University
Stephen G. Pyne, University of WollongongFollow

RIS ID

33602

Publication Details

Ritthiwigrom, T., Willis, A. C. & Pyne, S. G. (2010). Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor. The Journal of Organic Chemistry, 75 (3), 815-824.

Abstract

A flexible method for the diastereoselective total synthesis of the pyrrolizidine alkaloids Uniflorine A, casuarine, australine, and 3-epi-australine and the unnatural epimer 3,7-di-epi-australine from a common chiral 2,5-dihydropyrrole precursor is described.