Multiple species of bacteria are able to sequester the host zymogen plasminogen to the cell surface. Once localised to the bacterial surface, plasminogen can act as a cofactor in adhesion, or, following activation to plasmin, provide a source of potent proteolytic activity. Numerous bacterial plasminogen receptors have been identified, and the mechanisms by which they interact with plasminogen are diverse. Here we provide an overview of bacterial plasminogen receptors and discuss the diverse role bacterial plasminogen acquisition plays in the relationship between bacteria and the host.
Additional Grant Number
Life Sciences Commons, Physical Sciences and Mathematics Commons, Social and Behavioral Sciences Commons
Sanderson-Smith, M. L., De Oliveira, D. M. P., Ranson, M. & McArthur, J. D. (2012). Bacterial plasminogen receptors: mediators of a multifaceted relationship. Journal of Biomedicine and Biotechnology, 2012 (N/A), 1-14.