4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) is a highly effective coupling reagent used for both amide synthesis and for the preparation of esters. The advantages of using DMTMM as a coupling reagent include excellent product yields and the possibility that reactions can be performed in one step at room temperature and under atmospheric conditions. Readily removed and solubilising solvents (e.g. MeOH, EtOH, i-PrOH) including water, can be used in reactions with DMTMM and no drying requirements are needed for the reaction solvents. Furthermore, no additives are required and acids can be activated in situ.