A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

Authors

Karina Gornall, University of WollongongFollow
Siritron Samosorn, University of WollongongFollow
Bongkot Tanwirat, Srinakharinwirot University, Thailand
Apichart Suksamrarn, Ramkhamhaeng University, Thailand
John B. Bremner, University of WollongongFollow
Michael J. Kelso, University of WollongongFollow
Jennifer L. Beck, University of WollongongFollow

RIS ID

33634

Publication Details

Gornall, K., Samosorn, S., Tanwirat, B., Suksamrarn, A., Bremner, J. B., Kelso, M. J. & Beck, J. L. (2010). A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives. Chemical Communications, 46 (35), 6602-6604.

Abstract

ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands. © 2010 The Royal Society of Chemistry.