Phytochemical studies on Stemona plants: isolation of stemofoline alkaloids

Authors

Thanapat Sastraruji, University of WollongongFollow
Araya Jatisatienr, Chiang Mai University
Stephen G. Pyne, University of WollongongFollow
Alison T. Ung, University of WollongongFollow
Wilford Lie, University of WollongongFollow
Morwenna C. Williams, University of WollongongFollow

RIS ID

12879

Publication Details

Sastraruji, T., Pyne, S. G., Ung, A. T., Lie, W., Williams, M. C. & Jatisatienr, A. (2005). Phytochemical studies on Stemona plants: isolation of stemofoline alkaloids. Journal of Natural Products, 68 (12), 1763-1767.

Abstract

Six new stemofoline alkaloids, (2‘R)-hydroxystemofoline (5), (3‘R)-stemofolenol (6), (3‘S)-stemofolenol (7), 1‘,2‘-didehydrostemofoline-N-oxide (8), the first C₁₉ stemofoline alkaloid, methylstemofoline (9), and the first glycosidated Stemona alkaloid, stemofolinoside (10), and three known alkaloids, (2‘S)-hydroxystemofoline (2), (11Z)-1‘,2‘-didehydrostemofoline (3), and (11E)-1‘,2‘-didehydrostemofoline (4), have been isolated from a root extract of an unidentified Stemona species. The structure and relative configuration of these new alkaloids have been determined by spectral data interpretation and from semisynthetic studies.