N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents
RIS ID
24416
Abstract
Arange of N-phenethyl,N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared byN-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structureactivity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC50 value of 0.19 microM.
Publication Details
Matesic, L., Locke, J., Bremner, J. B., Pyne, S. G., Skropeta, D., Ranson, M. & Vine, K. L. (2008). N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents. Bioorganic and Medicinal Chemistry, 16 (6), 3118-3124.