Treatment of urothelial cells with lipopolysaccharide from enteropathogenic E. coli reduces stretch induced
INTRODUCTION AND OBJECTIVES: Urinary tract infection (UTI). commonly caused by Escherichia coli , is experienced by 50% of all women at least once during their lifetime. The symptoms of UTI include increased voiding frequency and urgency, usually accompanied by a sensation of burning pain and foul smelling urine. ATP released from bladder urothelium is an important molecule for signal· ling urinary urgency. The aim of the current study was to examine the effect of lipopolysaccharide (LPS) from E. coli on stretch-induced ATP release from urothelial RT4 celis in culture.