Law enforcement has always been problematic in Indonesia and has been challenging for government agencies, including the enforcement of food safety regulation. Indonesian government has promulgated several regulations on food safety such as Act 18/2012 on Food and Government Regulation No. 28 of 2004 on Food Safety, Quality and Nutrition. Also, the government has established the National Agency for Drug and Food Control to monitor and supervise the food sector. However, food safety offense such as food adulteration is still easily found in almost every area in Indonesia and causing serious illnesses and economic losses. In addressing food safety in Indonesia, this study aims to analyze the difficulties facing to enforce the law and regulations of food safety in Indonesia. This study investigates the factors which negatively influence the attempt to achieve food safety. With library research, the legislation, legal theory, and other secondary data will be analyzed to then crystallized into conclusions as the characteristics of doctrinal research. This study concludes there are two categories of factors affecting the enforcement of food safety law and regulations namely internal and external factors.