Establishing an acceptable user-centred electronic health record (EHR) system is a challenging task for healthcare providers due to the need for such systems to meet the requirements of its user population. Concerned nurses are the main end-users of EHR systems. Based on knowledge of evidence-based management (EBM) and the issues (goals and methods) of Health Information Systems (HIS) evaluation, this research was performed in four regional teaching hospitals by adopting a quantitative approach research design to perform “goal-based evaluation” research. The results of Path Analysis indicated that 17 of 21 hypotheses were accepted in this study. In addition, the results of One-way ANOVA with Scheff test comparisons indicated that Age is the most important variable in measuring System Quality, Service Quality, Safety Quality, User Use and User Satisfaction; Education is important in measuring Service Quality; and Seniority is important in measuring System Quality, Service Quality and User Use. Furthermore, the results of Linear regression indicated that only one hypothesis is affected by the demographic variable Education. In summary, this empirical investigation provided evidence-based knowledge to explain nurses’ opinions of EHR systems success, and to distinguish which demographic variables influence their viewpoints of using such systems in southern Taiwan.