The Illawarra Health and Medical Research Institute is a partnership between the University of Wollongong and the South Eastern Sydney Illawarra Area Health Service. IHMRI's research focuses on health and medical issues that are common in the Illawarra region and is aimed at improving the health and well being of the local community. IHMRI's goal is to foster research collaboration through the IHMRI Research Network, creating a centre of excellence and innovation that represents the focal point of health and medical research in this region.
Papers from 2015
Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice, Yinghua Yu, Yizhen Wu, Alexander M. Szabo, Sen Wang, Shijia Yu, Qing Wang, and Xu-Feng Huang
Investigation of optimized prompt gamma detection strategy for real-time Bragg Peak tracking in proton radiation therapy, Melek Zarifi, Yujin Qi, Susanna Guatelli, Brian F. Hutton, and Anatoly B. Rosenfeld
The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases, Rafaa Zeineddine and Justin J. Yerbury
Gender differences in cognitive deficits in schizophrenia with and without diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, and Xu-Feng Huang
Glucose disturbances in first-episode drug-naïve schizophrenia: relationship to psychopathology, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, Hui-Mei An, Giovana B. Zunta-Soares, Xu-Feng Huang, and Jair C. Soares
Papers from 2014
Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease, Sarah Abbott, Hongyun Li, Sonia Sanz Munoz, Bianca Knoch, Marijka Batterham, Karen E. Murphy, Glenda M. Halliday, and Brett Garner
Hypothermia protects human neurons, Ana Antonic, Mirella Dottori, Jessie Leung, Kate Sidon, Peter Batchelor, William J. Wilson, Malcolm R. Macleod, and David W. Howells
How to diagnose and manage resistant hypertension, Leonard F. Arnolda and Yi Zhang
A vision for chronic disease prevention and intervention research: report from a workshop, Fred D. Ashbury, Julian Little, John P.A Ioannidis, Nancy Kreiger, Lyle J. Palmer, Clare Relton, and Peter Taylor
Metacognitive Narrative Psychotherapy for people diagnosed with schizophrenia: an outline of a principle-based treatment manual, Rebecca Bargenquast and Robert Schweitzer
Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels, Géza Berecki, Norelle L. Daly, Y H. Huang, S Vink, David J. Craik, Paul F. Alewood, and David J. Adams
Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation, Géza Berecki, Jeffrey R. McArthur, Hartmut Cuny, Richard J. Clark, and David J. Adams
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism, Archana Bhaskaracharya, Phuong Dao-Ung, Iman Jalilian, Mari Spildrejorde, Kristen K. Skarratt, Stephen Fuller, Ronald Sluyter, and Leanne Stokes
Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain, Matthew J. Bird, Karina Needham, Ann E. Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E. Thornton, Clare L. Parish, Bryony A. Nayagam, Martin F. Pera, David R. Thorburn, Lachlan H. Thompson, and Mirella Dottori
Cancer biology: molecular and genetic basis, Ulrich A. Bommer, Kara L. Vine, and Oncology Education Committee Cancer Council Australia
Trust, continuity and agency: keys to understanding older patients' attitudes to general practice trainees, Andrew Bonney, Sandra C. Jones, Donald C. Iverson, and Christopher Magee
Comment on: Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulation (sic) in rats, Danielle Camer and Xu-Feng Huang
The endothelin pathway: a protective or detrimental target of bardoxolone methyl on cardiac function in patients with advanced chronic kidney disease?, Danielle Camer and Xu-Feng Huang
The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications, Danielle Camer, Yinghua Yu, Alexander Szabo, and Xu-Feng Huang
Increased expression of astrocyte markers in schizophrenia: association with neuroinflammation, Vibeke Sørensen Catts, Jenny Wong, Stu Gregory Fillman, Samantha J. Fung, and Cynthia S. Weickert
Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice, David Cheng, Jac Kee Low, Warren Logge, Brett Garner, and Tim Karl
Novel behavioural characteristics of female APPswe/PS1ΔE9 double transgenic mice, David Cheng, Jac Kee Low, Warren Logge, Brett Garner, and Tim Karl
The role of Src in colon cancer and its therapeutic implications, Jiezhong Chen, Aymen Elfiky, Mei Han, Chen Chen, and M Wasif Saif
Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways, Jiezhong Chen, Renfu Shao, Li Li, Zhi Ping Xu, and Wenyi Gu
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets, Sandeep Chhabra, Alessia Belgi, Peter Bartels, Bianca J. van Lierop, Samuel D. Robinson, Shiva N. Kompella, Andrew Hung, Brid P. Callaghan, David J. Adams, Andrea J. Robinson, and Raymond Norton
Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway, Mengna Chi, Yan Ye, Xu Dong Zhang, and Jiezhong Chen
Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants, Simon M. Cook, Amanda Skora, Mark J. Walker, Martina L. Sanderson-Smith, and Jason D. McArthur
Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis, Timothy A. Couttas, Nupur Kain, Benjamin Daniels, Xin Ying Lim, Claire E. Shepherd, Jillian Kril, Russell Pickford, Hongyun Li, Brett Garner, and Anthony Don
Emotion perception and electrophysiological correlates in Huntington's disease, Rodney J. Croft, F Mckernan, M Gray, A Churchyard, and Nellie Georgiou-Karistianis
Finding measures of clinical placements quality for pre-service health services training: challenges of definition and search strategy construction, Anne Cusick, Marie Heydon, Katherine Caldwell, and Linda Cohen
Validating the Western Neuro Sensory Stimulation Profile for patients with severe traumatic brain injury who are slow-to-recover, Anne Cusick, Natasha Lannin, Robyn Hanssen, and Jeanine Allaous
Expression and purification of chaperone-active recombinant clusterin, Rebecca Dabbs and Mark R. Wilson
Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats, Michael De Santis, Bo Pan, Jiamei Lian, Xu-Feng Huang, and Chao Deng
Cell and gene therapy for friedreich ataxia: Progress to date, Marguerite V. Evans-Galea, Alice Pebay, Mirella Dottori, Louise A. Corben, Sze Hwee Ong, Paul J. Lockhart, and Martin B. Delatycki
Implementing a regional oncology information system: approach and lessons learned, W K. Evans, Fred D. Ashbury, G L. Hogue, A Smith, and J Pun
Novel implications of Lingo-1 and its signaling partners in schizophrenia, F Fernandez-Enright, J L. Andrews, K A. Newell, C Pantelis, and Xu-Feng Huang
Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses, Nicholas A. Gad, Jasminka Mizdrak, David I. Pattison, Michael J. Davies, Roger J. W Truscott, and Joanne F. Jamie
GluN2B protein deficits in the left, but not the right, hippocampus in schizophrenia, Amy Geddes, Xu-Feng Huang, and Kelly Newell
Menses, fertility and pregnancy following the use of balloon tamponade technology in the management of postpartum haemorrhage, Christos Georgiou
Semantic monitoring and compensation in socio-technical processes, Yingzhi Gou, Aditya Ghose, Chee Fon Chang, Hoa Dam, and Andrew Alexis Miller
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms, Leslie I. Grad, Justin J. Yerbury, Bradley J. Turner, William C. Guest, Edward Pokrishevsky, Megan A. O'Neill, Anat Yanai, Judith M. Silverman, Rafaa Zeineddine, Lisa Corcoran, Janet Kumita, Leila Luheshi, Masoud Yousefi, Bradley M. Coleman, Andrew Hill, Steven S. Plotkin, Ian R. Mackenzie, and Neil R. Cashman
Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods, Dhanushka Gunawardena, Kirubakaran Shanmugam, Suresh Govindaraghavan, Mitchell Low, Louise Bennett, Richard Head, Lezanne Ooi, and Gerald Münch
Directing Human Induced Pluripotent Stem Cells into a Neurosensory Lineage for Auditory Neuron Replacement, Niliksha Gunewardene, Nicole Van Bergen, Duncan E. Crombie, Karina Needham, Mirella Dottori, and Bryony A. Nayagam
A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism, Dian Handayani, Barbara J. Meyer, Jiezhong Chen, Simon H. J Brown, Todd W. Mitchell, and Xu-Feng Huang
Dyslipidemia awareness, treatment, control and influence factors among adults in the Jilin province in China: a cross-sectional study, Huan He, Yaqin Yu, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Chang Wang, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, and Yawen Liu
Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats, Meng He, Qingsheng Zhang, Chao Deng, Hongqin Wang, Jiamei Lian, and Xu-Feng Huang
Intrapericardial injections using a novel technique, Vasyl Holobotovskyy, Leonard F. Arnolda, and Douglas J. McKitrick
Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors, Gene Hopping, C-I Anderson Wang, Ron C. Hogg, Simon T. Nevin, Richard J. Lewis, David J. Adams, and Paul F. Alewood
Possible association between DBH 19 bp insertion/deletion polymorphism and clinical symptoms in schizophrenia with tardive dyskinesia, Li Hui, Mei Han, Xu-Feng Huang, Min Jie Ye, Ke Zheng, Jin Cai He, Meng Han Lv, Bao Hua J. Zhang, Jair C. Soares, and Xiang Yang Zhang
A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells, Thomas S. Klaric, Paul Q. Thomas, Mirella Dottori, Wai Khay Leong, Simon A. Koblar, and Martin D. Lewis
Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels, Julie K. Klint, Géza Berecki, Thomas Durek, Mehdi Mobli, Oliver Knapp, Glenn F. King, David J. Adams, Paul F. Alewood, and Lachlan D. Rash
Informal mining in livelihood diversification: mineral dependence and rural communities in Lao PDR, Kuntala Lahiri-Dutt, Kim Alexander, and Chansouk Insouvanh
Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways, Jiamei LIAN, Xu-Feng Huang, Nagesh B. Pai, and Chao Deng
Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin Isolated from the venom of the Australian scorpion Urodacus yaschenkoi, Karen S. Luna Ramirez, Adam Bartok, Rita Restano-Cassulini, Veronica Quintero-Hernandez, Fredy I. V Coronas, Janni Christensen, Christine E. Wright, Gyorgy Panyi, and Lourival D. Possani
Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion, Karen S. Luna Ramirez, Marc-Antoine Sani, Jesus Silva-Sanchez, Juana María Jimenez-Vargas, Fernando Reyna-Flores, Kenneth D. Winkel, Christine E. Wright, Lourival D. Possani, and Frances Separovic
Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing, Diane Ly, Jude Taylor, James A. Tsatsaronis, Mercedes M. Monteleone, Amanda Skora, Cortny A. Donald, Tracy A. Maddocks, Victor Nizet, Nicholas P. West, Marie Ranson, Mark J. Walker, Jason D. McArthur, and Martina L. Sanderson-Smith
Separate mechanisms for age-related truncation and racemisation of peptide-bound serine, Brian Lyons, Joanne F. Jamie, and Roger J.W Truscott
Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus), Brian Lyons, Peter Karuso, Joanne Jamie, Mukoma F. Simpanya, Frank Giblin, and Roger J. W Truscott
Spontaneous cyclization of polypeptides with a penultimate Asp, Asn or isoAsp at the N-terminus and implications for cleavage by aminopeptidase, Brian Lyons, Ann H. Kwan, and Roger J. W Truscott
Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics, Natalie Matosin, Francesca Fernandez-Enright, Elisabeth Frank, Chao Deng, Jenny Wong, Xu-Feng Huang, and Kelly Newell
Negativity towards negative results: a discussion of the disconnect between scientific worth and scientific culture, Natalie Matosin, Elisabeth Frank, Martin Engel, Jeremy S. Lum, and Kelly Newell
A novel population health data source to inform local planning: the SIMLR Study, Darren J. Mayne, Andrew Bonney, Bryan Jones, Lawrence Bott, Stephen Andersen, Peter Caputi, and Donald C. Iverson
Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease, Karen E. Murphy, Amanda M. Gysbers, Sarah K. Abbott, Nahid Tayebi, Woojin S. Kim, Ellen Sidransky, Anthony Cooper, Brett Garner, and Glenda M. Halliday
Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells, Karina Needham, Tomoko Hyakumura, Niliksha Gunewardene, Mirella Dottori, and Bryony A. Nayagam
Post-testicular sperm maturation and identification of an epididymal protein in the Japanese quail (Coturnix coturnix japonica), Brett Nixon, Katherine A. Ewen, Klara M. Krivanek, John Clulow, Grahame Kidd, Heath Ecroyd, and Russell C. Jones
The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergy, Martin Reichel, Tanja Richter-Schmidinger, Christiane Muhle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, and Johannes Kornhuber
Secretion of acid sphingomyelinase is affected by its polymorphic signal peptide, Cosima Rhein, Martin Reichel, Christiane Muhle, Andrea Rotter, Sibylle G. Schwab, and Johannes Kornhuber
Comparison of tear lipid profile among basal, reflex, and flush tear samples, Athira Rohit, Fiona Stapleton, Simon Brown, Todd W. Mitchell, and Mark D. P Willcox
Effectiveness of individual-focused interventions to prevent chronic disease, Sara Saeed, Mohammad Golfam, Reed Beall, Fred D. Ashbury, Lyle J. Palmer, and Julian Little
A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development, Martina L. Sanderson-Smith, David De Oliveira, Julien Guglielmini, David J. McMillan, Therese Vu, Jessica K. Holien, Anna Henningham, Andrew C. Steer, Debra E. Bessen, James B. Dale, Nigel Curtis, Bernard W. Beall, Mark J. Walker, Michael W. Parker, Jonathan R. Carapetis, Laurence Van Melderen, Kadaba S. Sriprakash, Pierre R. Smeesters, and The M Protein Study Group
Biological insights from 108 schizophrenia-associated genetic loci, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Hailiang Huang, and Sibylle G. Schwab
Engineering of bismuth oxide nanoparticles to induce differential biochemical activity in malignant and nonmalignant cells, Callum Stewart, Konstantin Konstantinov, Marjorie McDonald, Kathrin Bogusz, Dean Cardillo, Sianne Oktaria, Dongqi Shi, Michael L. F Lerch, Thierry Devers, Stephanie Corde, Anatoly B. Rosenfeld, and Moeava Tehei
Heme consumption reduces hepatic triglyceride and fatty acid accumulation in a rat model of NAFLD fed westernized diet, Soon Yew Tang, Irwin Kee M. Cheah, Pei Ern Ng, Aina Hoi, and Andrew M. Jenner
Foods and food components in the Mediterranean diet: supporting overall effects, Linda Tapsell
Polymorphism in casein protein aggregation and amyloid fibril formation, David Thorn, Heath Ecroyd, and John A. Carver
A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite, Phuong T. Tran, Simon Brown, Todd W. Mitchell, Kai Matuschewski, Paul J. Mcmillan, Kiaran Kirk, Matthew W. A Dixon, and Alexander Maier
Old proteins and the Achilles heel of mass spectrometry. The role of proteomics in the etiology of human cataract, Roger J. W Truscott and Michael Friedrich
Host responses to group A Streptococcus: cell death and inflammation, James A. Tsatsaronis, Mark J. Walker, and Martina L. Sanderson-Smith
Disease manifestations and pathogenic mechanisms of group A Streptococcus, Mark J. Walker, Timothy Barnett, Jason D. McArthur, Jason Cole, Christine Gillen, Anna Henningham, K S. Sriprakash, Martina L. Sanderson-Smith, and Victor Nizet
Awareness, treatment, control of diabetes mellitus and the risk factors: survey results from Northeast China, Chang Wang, Yaqin Yu, Xiang Yang Zhang, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Huan He, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, and Yawen Liu
Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates, Zhen Wang, Brian Lyons, Roger J. W Truscott, and Kevin L. Schey
Serotonintransportergen und stressreagibilität bei unipolarer depression, Hanne Welper, A Aller, Vera Guttenthaler, Susanne Hofels, Leonhard Lennertz, Ute Pfeiffer, Sibylle G. Schwab, and Astrid W. Zobel
The ratchet effect: dramatic and sustained changes in health care utilization following admission to hospital with chronic disease, David Whyatt, Raji Tenneti, Julie Marsh, Sarah E. Bolt, Anna Kemp, Laura Firth, Kevin Murray, Berwin Turlach, and Alistair Vickery
The ecological fallacy of the role of age in chronic disease and hospital demand, David Whyatt, Raji Tenneti, Julie Marsh, Anna Kemp, Laura Firth, Kevin Murray, Berwin Turlach, and Alistair Vickery
Regulation of a TrkB Alternative Transcript by microRNAs, Jenny Wong
Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet, Yizhen Wu, Yinghua Yu, Alexander Szabo, Mei Han, and Xu-Feng Huang
Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, and Xu-Feng Huang
Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, Jiamei Lian, and Xu-Feng Huang
Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats, Qingsheng Zhang, Jiamei Lian, Meng He, Chao Deng, Hongqin Wang, and Xu-Feng Huang
Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition, Hua Zhao, Kalani Ruberu, Hongyun Li, and Brett Garner
Papers from 2013
An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids, Sarah K. Abbott, Andrew M. Jenner, Todd W. Mitchell, Simon H. Brown, Glenda M. Halliday, and Brett Garner
Global fatty acid composition is altered in Parkinson's disease anterior cingulate cortex, S K. Abbott, G M. Halliday, and B Garner
Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels, David J. Adams and Géza Berecki
Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease, Osvaldo P. Almeida, Griselda J. Garrido, Christopher Etherton-Beer, Nicola Lautenschlager, Leonard F. Arnolda, Helman Alfonso, and Leon Flicker
The "DGPPN-Cohort": a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients, Heike Anderson-Schmidt, Lothar Adler, Chadiga Aly, Ion-George Anghelescu, Michael Bauer, Jessica Baumgartner, Joachim Becker, Roswitha Bianco, Thomas Becker, and Sibylle G. Schwab
Novel implications of Lingo-1 and its signalling partners in the Dorsolateral prefrontal cortex in schizophrenia, Jessica L. Andrews, Kelly A. Newell, Xu-Feng Huang, and Francesca Fernandez-Enright
Structural and functional aspects of hetero-oligomers formed by the small heat shock proteins αB-crystallin and HSP27, J Andrew Aquilina, Sudichhya Shrestha, Amie M. Morris, and Heath Ecroyd
Burden and support needs of carers of persons with borderline personality disorder: a systematic review, Rachel Bailey and Brin F. S Grenyer
Increased apolipoprotein D dimer formation in Alzheimer's disease hippocampus is associated with lipid conjugated diene levels, Surabhi Bhatia, Andrew M. Jenner, Hongyun Li, Kalani Ruberu, Adena S. Spiro, Claire E. Shepherd, Jillian J. Kril, Nupur Kain, Anthony Don, and Brett Garner
Men who have sex with men, infectious syphilis and HIV coinfection in inner Sydney: results of enhanced surveillance, Susan J. Botham, Kelly-Anne Ressler, Patrick Maywood, Kirsty G. Hope, Chris P. Bourne, Stephen J. Conaty, Mark J. Ferson, and Darren J. Mayne