Substance p and serotonergic inputs to sympathetic preganglionic neurons

Authors

Paul M. Pilowsky, Flinders University
Ida J. Llewellyn-Smith, Flinders University
Jane B. Minson, Flinders University
Leonard F. Arnolda, Flinders UniversityFollow
John P. Chalmers, Flinders University

RIS ID

109232

Publication Details

Pilowsky, P. M., Llewellyn-Smith, I. J., Minson, J. B., Arnolda, L. F. & Chalmers, J. P. (1995). Substance p and serotonergic inputs to sympathetic preganglionic neurons. Clinical and Experimental Hypertension, 17 (1-2), 335-344.

Abstract

Sympathetic preganglionic neurons are the final central links in the sympathetic pathways that control the heart and blood vessels. The neurotransmitters present in the supraspinal pathways that control the activity of sympathetic preganglionic neurons include amino acids, amines and peptides. In this paper we discuss evidence that suggests a role for serotonin and substance P in these pathways. Both of these neurotransmitters are present in bulbospinal neurons. Our results suggest that they have an important physiological role in the central regulation of blood pressure.