Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia

Authors

David J. Adams, University of New South WalesFollow
Peter W. Gage, University of New South Wales
Owen P. Hamill, University of New South Wales

RIS ID

106312

Publication Details

Adams, D. J., Gage, P. W. & Hamill, O. P. (1976). Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia. Brain Research, 115 (3), 506-511.

Abstract

Inhibitory postsynaptic currents (IPSCs) which were recorded in voltage-clamped neurones in buccal ganglia of Aplysia were blocked by D-tubocurarine and lengthened by prostigmine. Their amplitude varied with membrane potential and the mean null potential was --58 mV. The conductance change producing the IPSCs was in the range 1-5 x 10 -7 ~2-1. The decay of IPSCs was exponential, with a mean time constant of decay (z) of 12 msec at a membrane potential of --40 mV (20 °C). z varied exponentially with membrane potential, increasing e-fold for a hyperpolarization of 155 mV. It was concluded that the voltage sensitivity of the decay of synaptic conductance is not related to the ion-selectivity of the ionophore.