The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII

Authors

Joanne T. Blanchfield, University of Queensland
Julie L. Dutton, University of Queensland
Ron C. Hogg, University of Queensland
David J. Craik, University of Queensland
David J. Adams, University of QueenslandFollow
Richard J. Lewis, University of QueenslandFollow
Paul F. Alewood, University of Queensland
Istvan Toth, University of Queensland

RIS ID

106080

Publication Details

Blanchfield, J., Dutton, J., Hogg, R., Craik, D., Adams, D., Lewis, R., Alewood, P. & Toth, I. (2001). The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII. Letters in Peptide Science, 8 (3-5), 235-239. Letters in Peptide Science

Abstract

The α-conotoxin MII is a 16 amino acid long peptide toxin isolated from the marine snail, Conus magus. This toxin has been found to be a highly selective and potent inhibitor of neuronal nicotinic acetylcholine receptors of the subtype α3β2. To improve the bioavailability of this peptide, we have coupled to the N-terminus of conotoxin MII, 2-amino-D,L-dodecanoic acid (Laa) creating a lipidic linear peptide which was then successfully oxidised to produce the correctly folded conotoxin MII construct.