Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding
RIS ID
105259
Abstract
Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously "unfoldable" miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.
Publication Details
de Araujo, A. Dantas., Callaghan, B., Nevin, S. T., Daly, N. L., Craik, D. J., Moretta, M., Hopping, G., Christie, M. J., Adams, D. J. & Alewood, P. F. (2011). Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie International Edition, 50 (29), 6527-6529.