Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding

Authors

Aline Dantas de Araujo, University of Queensland
Brid P. Callaghan, RMIT University
Simon T. Nevin, University of Queensland
Norelle L. Daly, University of Queensland
David J. Craik, University of Queensland
Melissa Moretta, University of Sydney
Gene Hopping, University of Queensland
MacDonald J. Christie, University of Sydney
David J. Adams, RMIT UniversityFollow
Paul F. Alewood, University of Queensland

RIS ID

105259

Publication Details

de Araujo, A. Dantas., Callaghan, B., Nevin, S. T., Daly, N. L., Craik, D. J., Moretta, M., Hopping, G., Christie, M. J., Adams, D. J. & Alewood, P. F. (2011). Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie International Edition, 50 (29), 6527-6529.

Abstract

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously "unfoldable" miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.