Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia



Publication Details

Schwab, S. G., Kusumawardhani, A. A.A.A., Dai, N., Qin, W., Wildenauer, M. D.B., Agiananda, F., Amir, N., Antoni, R., Arsianti, T., Asmarahadi, A., Diatri, H., Djatmiko, P., Irmansyah, I., Khalimah, S., Kusumadewi, I., Kusumaningrum, P., Lukman, P. R., Mustar, L., Nasrun, M. W., Naswati, S., Prasetiyawan, P., Semen, G. M., Siste, K., Tobing, H., Widiasih, N., Wiguna, T., Wulandari, W., Indonesian Schizophrenia Genetics Consortium, , Benyamin, B. & Wildenauer, D. B. (2013). Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. Schizophrenia Research, 147 (1), 46-52.


Background Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background. Methods We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR–RFLP assay for confirmation of rs1344706 genotypes. Results We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, OR = 1.155, 95%, CI 1.025–1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706. Conclusion We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.

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