Max Lam, Institute of Mental Health
Chia Chen, Massachusetts General Hospital
Zhiqiang Li, Shanghai Jiao Tong UniversityFollow
Alicia Martin, Massachusetts General Hospital
Julien Bryois, Karolinska Institutet
Xixian Ma, Chinese Academy Of Sciences
Helena Gaspar, King's College London
Masashi Ikeda, Fujita Health University
Beben Benyamin, University of Queensland
Brielin Brown, Columbia University
Ruize Liu, Massachusetts General Hospital
Wei Zhou, Chinese Academy Of Sciences
Lili Guan, Peking University
Yoichiro Kamatani, University of Tokyo
Sung Kim, Chonnam National University
Michiaki Kubo, RIKEN Advanced Science Institute
Agung A.A.A Kusumawardhani, University of Indonesia
Chih Liu, National Taiwan University Hospital
Hong Ma, Shanghai University
Sathish Periyasamy, University of Queensland
Atsushi Takahashi, RIKEN Advanced Science Institute
Zhida Xu, University Medical Center Utrecht
Hao Yu, Peking University
Feng Zhu, Liaoning Technical University
Wei Chen, National Taiwan University Hospital
Stephen Faraone, State University of New York
Stephen Glatt, State University of New York
Lin He, Shanghai Jiao Tong University
Steven Hyman, Harvard University
Hai Hwu, National Taiwan University Hospital
Steven McCarroll, Harvard University
Benjamin M. Neale, Massachusetts General Hospital
Pamela Sklar, Icahn School of Medicine at Mount Sinai
Dieter B. Wildenauer, University of Western Australia
Xin Yu, Xiamen Golden Dragon Automobile Electronic Co Ltd
Dai Zhang, Peking University
Bryan J. Mowry, University of Queensland
Jimmy Lee, Institute of Mental Health, Singapore
Peter A. Holmans, Cardiff University
Shuhua Xu, Chinese Academy Of Sciences
Patrick Sullivan, University of Notre DameFollow
Stephan Ripke, Stanford University
Michael O'Donovan, Cardiff University
Mark Daly, Massachusetts General Hospital
Shengying Qin, Shanghai Jiao Tong University
Pak Sham, University of Hong Kong
Nakao Iwata, Fujita Health University
Kyung-Han Hong, Massachusetts Institute of Technology
Sibylle G. Schwab, University of WollongongFollow
Weihua Yue, Peking University
Ming Tsuang, University of California
Jianjun Liu, Hunan University
Xiancang Ma, Xi'an Jiaotong University
Rene S. Kahn, University Medical Center Utrecht
Yongyong Shi, Shanghai Jiao Tong University
Hailiang Huang, Massachusetts General Hospital



Publication Details

Lam, M., Chen, C., Li, Z., Martin, A. R., Bryois, J., Ma, X., Gaspar, H., Ikeda, M., Benyamin, B., Brown, B. C., Liu, R., Zhou, W., Guan, L., Kamatani, Y., Kim, S., Kubo, M., Kusumawardhani, A., Liu, C., Ma, H., Periyasamy, S., Takahashi, A., Xu, Z., Yu, H., Zhu, F., Chen, W., Faraone, S., Glatt, S., He, L., Hyman, S., Hwu, H., McCarroll, S., Neale, B., Sklar, P., Wildenauer, D., Yu, X., Zhang, D., Mowry, B., Lee, J., Holmans, P., Xu, S., Sullivan, P., Ripke, S., O¿Donovan, M., Daly, M., Qin, S., Sham, P., Iwata, N., Hong, K., Schwab, S., Yue, W., Tsuang, M., Liu, J., Ma, X., Kahn, R., Shi, Y. & Huang, H. (2019). Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics, 51 1670-1678.


Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.



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