Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

Authors

Hitesh Kulhari, Central University of Gujarat
Ashok Jangid, Central University of Gujarat
David J. Adams, University of WollongongFollow

RIS ID

136192

Publication Details

Kulhari, H., Jangid, A. K. & Adams, D. J. (2019). Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery. Methods in Molecular Biology, 1974 195-201.

Abstract

Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.