RIS ID

136192

Publication Details

Kulhari, H., Jangid, A. K. & Adams, D. J. (2019). Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery. Methods in Molecular Biology, 1974 195-201.

Abstract

Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/978-1-4939-9220-1_14