Murat Yucel, Monash University
Erin Oldenhof, Monash University
Serge Ahmed, University of Bordeaux
David Belin, University of Cambridge
Joel Billieux, University of Luxembourg
Henrietta Bowden-Jones, Imperial College
Adrian Carter, Monash University
Samuel Chamberlain, Cambridge and Peterborough NHS Foundation Trust, University of Cambridge
Luke Clark, University of British Columbia
Jason Connor, University of Queensland
Mark Daglish, Royal Brisbane & Women's Hospital, University of Queensland
Geert Dom, University of Antwerp
Pinhas Dannon, Tel Aviv University, Israel
Theodora Duka, University of Sussex
Maria Fernandez-Serrano, University of Jaen
Matt Field, University of Sheffield
Ingmar Franken, Erasmus University Rotterdam
Rita Goldstein, Icahn School of Medicine at Mount Sinai
Raul Gonzalez, Florida International University
Anna Goudriaan, University of Amsterdam
Jon Grant, University of Chicago
Matthew Gullo, University of Queensland
Robert Hester, University of Melbourne
David Hodgins, University of Calgary
Bernard Le Foll, University of Toronto, Centre for Addiction and Mental Health
Rico Lee, Monash University
Anne Lingford-Hughes, Imperial College
Valentina Lorenzetti, Australian Catholic Unversity
Scott Moeller, Stony Brook University
Marcus Munafo, University of Bristol
Brian Odlaug, Lundbeck A/S, Copenhagen University
Marc Potenza, Connecticut Council on Problem Gambling, Yale University, Connecticut Mental Health Center
Rebecca A. Segrave, Monash UniversityFollow
Zsuzsika Sjoerds, Max-Planck Institute for Human Cognitive and Brain Sciences, Leiden University
Nadia Solowij, University of Wollongong, Australian Centre for Cannabinoid Clinical and Research ExcellenceFollow
Wim Van Den Brink, University of Amsterdam
Ruth Van Holst, University of Amsterdam
Valerie Voon, University of Cambridge
Reinout Wiers, University of Amsterdam
Leonardo Fontenelle, Monash University
Antonio Verdejo-Garcia, Monash University



Publication Details

Yucel, M., Oldenhof, E., Ahmed, S. H., Belin, D., Billieux, J., Bowden-Jones, H., Carter, A., Chamberlain, S. R., Clark, L., Connor, J., Daglish, M., Dom, G., Dannon, P., Duka, T., Fernandez-Serrano, M. Jose., Field, M., Franken, I., Goldstein, R. Z., Gonzalez, R., Goudriaan, A. E., Grant, J. E., Gullo, M. J., Hester, R., Hodgins, D. C., Le Foll, B., Lee, R. S. C., Lingford-Hughes, A., Lorenzetti, V., Moeller, S. J., Munafo, M. R., Odlaug, B., Potenza, M. N., Segrave, R., Sjoerds, Z., Solowij, N., Van Den Brink, W., van Holst, R. J., Voon, V., Wiers, R., Fontenelle, L. F. & Verdejo-Garcia, A. (2019). A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study. Addiction, 114 (6), 1095-1109.


Background: The US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. The RDoC framework comprises 39 functional constructs designed to be revised and refined, with the overall goal of improving diagnostic validity and treatments. This study aimed to reach a consensus among experts in the addiction field on the 'primary' RDoC constructs most relevant to substance and behavioural addictions.

Methods: Forty-four addiction experts were recruited from Australia, Asia, Europe and the Americas. The Delphi technique was used to determine a consensus as to the degree of importance of each construct in understanding the essential dimensions underpinning addictive behaviours. Expert opinions were canvassed online over three rounds (97% completion rate), with each consecutive round offering feedback for experts to review their opinions.

Results: Seven constructs were endorsed by ≥ 80% of experts as 'primary' to the understanding of addictive behaviour: five from the Positive Valence System (reward valuation, expectancy, action selection, reward learning, habit); one from the Cognitive Control System (response selection/inhibition); and one expert-initiated construct (compulsivity). These constructs were rated to be related differentially to stages of the addiction cycle, with some linked more closely to addiction onset and others more to chronicity. Experts agreed that these neuropsychological dimensions apply across a range of addictions.

Conclusions: The study offers a novel and neuropsychologically informed theoretical framework, as well as a cogent step forward to test transdiagnostic concepts in addiction research, with direct implications for assessment, diagnosis, staging of disorder, and treatment.



Link to publisher version (DOI)