Commentary: GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1

Authors

Yuanyi Xie, University of WollongongFollow
Xu-Feng Huang, University of WollongongFollow

RIS ID

130998

Publication Details

Xie, Y. & Huang, X. (2018). Commentary: GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1. Frontiers in Molecular Neuroscience, 11 315-1-315-3.

Abstract

It is with great interest we have read the article "GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1" (Zhou et al., 2018). Interestingly, this study showed that GLYX-13 prevents hippocampal N-methyl-D-aspartate receptor subtype 2B-Disrupted in schizophrenia 1 (GluN2B-DISC1) signaling and behavioural changes induced by schizophrenia-mimetic drug MK801 in mice. To confirm GluN2B directly regulating DISC1, these researchers showed that the effects of GLYX-13 were vanished after GluN2B knockdown in mice.