RIS ID

131148

Publication Details

Wang, X. & Yu, H. (2018). The effect of DNA backbone on the triplet mechanism of UV-induced thymine-thymine (6-4) dimer formation. Journal of Molecular Modeling, 24 (11), 319-1-319-9.

Abstract

Density functional theory calculations have been carried out to investigate the formation mechanism of the thymine-thymine (6-4) dimer ((6-4)TT), which is one of the main DNA lesions induced by ultraviolet radiation and is closely related to skin cancers. The DNA backbone was found to have nonnegligible effects on the triplet reaction pathway, particularly the reaction steps involving substantial base rotations. The mechanism for the isomerisation from (6-4)TT to its Dewar valence isomer (DewarTT) was also explored, confirming the necessity of absorbing a second photon. In addition, the solvation effects were examined and showed considerable influence on the potential energy surface.

Grant Number

ARC/FT110100034

Available for download on Wednesday, October 23, 2019

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